Changes in Skeletal Muscle Protein Metabolism Signaling Induced by Glutamine Supplementation and Exercise.
Carlos Flores Rodrigues JuniorGilson Masahiro MurataFrederico Gerlinger-RomeroRenato Tadeu NachbarGabriel Nasri Marzuca-NassrRenata GorjãoKaio Fernando VitzelSandro Massao HirabaraTania Cristina Pithon-CuriRui CuriPublished in: Nutrients (2023)
Five weeks of GS and/or RET induced muscle hypertrophy, as indicated by the increased CSAs of the EDL muscle fibers. The increase in CSA was mediated via the upregulated phosphorylation of Akt, 4E-BP1, p70S6k, and S6 in G animals and 4E-BP1 in T animals. In the EDL muscles from T animals, a decrease in proteasome activity, favoring a further increase in the CSA of the muscle fibers, was reported.