Cues from interfacial tissue development may guide regeneration including biological cues such as cell phenotype and growth factor signaling; structural cues such as extracellular matrix (ECM) deposition, ECM, and cell alignment; and mechanical cues such as compression, tension, shear, and the stiffness of the cellular microenvironment. In this review, we explore new discoveries in the field of interfacial biology related to ECM remodeling, cellular metabolism, and fate. Based on emergent findings across multiple disciplines, we lay out a framework for future innovations in the design of engineered strategies for interface regeneration. Many of the key mechanisms essential for interfacial tissue development and adaptation have high potential for improving outcomes in the clinic.
Keyphrases
- extracellular matrix
- stem cells
- growth factor
- ionic liquid
- molecular dynamics simulations
- perovskite solar cells
- electron transfer
- single cell
- cell therapy
- primary care
- wound healing
- bone mineral density
- current status
- mesenchymal stem cells
- adipose tissue
- metabolic syndrome
- risk assessment
- bone marrow
- body composition