ABCC2 c.-24 C>T single-nucleotide polymorphism was associated with the pharmacokinetic variability of deferasirox in Chinese subjects.

Kangna CaoGuanghui RenChengcan LuYao WangYanan TanJing ZhouYongjie ZhangYang LuNing LiXijing ChenDi Zhao

Published in: European journal of clinical pharmacology (2019)

ABCC2 c.-24 C>T was associated with the pharmacokinetic variability of deferasirox in Chinese subjects. This study revealed an important role of MRP2 in the pharmacokinetics of deferasirox and drew attention to drug combination with MRP2 inhibitors like cyclosporine and methotrexate in deferasirox therapy.

Keyphrases

working memory
high dose
single cell
emergency department
stem cells
low dose
drug induced
adverse drug