Differential DNA methylation of steatosis and non-alcoholic fatty liver disease in adolescence.

Phillip E MeltonM A BurtonK A LillycropK M GodfreyS RauschertD AndersonG C BurdgeT A MoriL J BeilinO T AyonrindeJ M CraigJ K OlynykJ D HolbrookC E PennellW H OddyE K MosesL A AdamsR C Huang

Published in: Hepatology international (2023)

We identified novel DNA methylation loci associated with NAFLD and serum liver biochemistry markers during adolescence, implicating putative dmCpG/gene regulatory pathways and providing insights for future mechanistic studies.

Keyphrases

dna methylation
genome wide
depressive symptoms
gene expression
insulin resistance
current status
high fat diet
copy number
case control
type diabetes
liver fibrosis
high fat diet induced
metabolic syndrome
adipose tissue