Contemporary Anti-Retroviral Drugs (ARVDs) Disrupt Follicular Development in Female Wistar Rats.

Aigbe Gregory OhihoinEsther Ngozi OhihoinIfeoma UjomuAirat BakareOladeji OlanrewajuArinze OkaforMercy OjetundeJoy Boluwatife AyoolaOluwagbemiga AinaOlusola Ajibaye Simon D Taylor-Robinson

Published in: Journal of experimental pharmacology (2023)

The study demonstrated a disruption in the reproductive hormones of female Wistar rats receiving anti-retroviral regimens containing EFV. Clinical studies are required to determine if these changes are seen in women receiving EFV-based treatment, as this may compromise reproductive function and predispose them to early menopause.

Keyphrases

polycystic ovary syndrome
postmenopausal women
pregnancy outcomes
metabolic syndrome
adipose tissue