Sorafenib Encapsulated Poly(ester amide) Nanoparticles for Efficient and Biosafe Prostate Cancer Therapy.
Shunli YuRuhe ZhangZhaoxiang XieZhi XiongShirong PengBingheng LiRuilin ZhuangJun WuHai HuangPublished in: ACS biomaterials science & engineering (2024)
Prostate cancer (PCa) with a high incidence worldwide is a serious threat to men's health. Despite the continuous development of treatment strategies for PCa in recent years, the long-term prognosis of patients is still poor. Hence, the discovery and development of novel, secure, and efficient therapeutic approaches hold significant clinical significance. Although sorafenib (SOR) displays potential as a therapeutic option for PCa, its clinical efficacy is hindered by drug resistance, limited water solubility, and rapid metabolism. Therefore, we proposed to prepare nanoparticles (named SOR@8P4 NPs) utilizing the phenylalanine-based poly(ester amide) polymer (8P4) as the drug carrier to enhance the solubility and drug stability of SOR and improve the therapeutic targeting and bioavailability. SOR@8P4 NPs had high stability and showed acid-responsive drug release at the acidic tumor microenvironment. Additionally, SOR@8P4 NPs demonstrated more remarkable anticancer, antimetastatic, and antiproliferative abilities in vitro , compared with those of free drugs. SOR@8P4 NPs showed high tumor targeting and significantly inhibited tumor growth in vivo . In summary, the drug delivery system of SOR@8P4 NPs provides new ideas for the clinical treatment of PCa.
Keyphrases
- cancer therapy
- prostate cancer
- drug delivery
- drug release
- oxide nanoparticles
- end stage renal disease
- public health
- ejection fraction
- newly diagnosed
- radical prostatectomy
- small molecule
- risk factors
- peritoneal dialysis
- drug induced
- prognostic factors
- health information
- benign prostatic hyperplasia
- human health
- combination therapy
- single cell
- smoking cessation
- replacement therapy