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Development and external validation of a head and neck cancer risk prediction model.

Craig D L SmithAlex D McMahonDonald M LyallMariél de Aquino GoulartGareth J InmanAlastair J RossMark GormleyTom DuddingGary John MacfarlaneMax RobinsonLorenzo RichiardiDiego SerrainoJerry PoleselCristina CanovaWolfgang AhrensClaire Mary HealyPagona LagiouIvana HolcatovaLaia Alemany VilchesAriana ZnoarTim WaterboerPaul J BrennanShama ViraniDavid I Conway
Published in: Head & neck (2024)
We developed and externally validated a HNC risk prediction model using the ARCAGE and UK Biobank studies, respectively. This model had moderate performance in the development population and acceptable performance in the validation dataset. Demographics and risk behaviors are strong predictors of HNC, and this model may be a helpful tool in primary dental care settings to promote prevention and determine recall intervals for dental examination. Future addition of HPV serology or genetic factors could further enhance individual risk prediction.
Keyphrases
  • healthcare
  • palliative care
  • oral health
  • genome wide
  • quality improvement
  • high grade
  • gene expression
  • pain management