Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis.

Ingo Winschel Anne Willing Jan Broder Engler Mark Walkenhorst Nina Kursawe Lars Binkle Marcel Seungsu Woo Lena Kristina Pfeffer Jana K Sonner Uwe Borgmeyer Sven Hendrik Hagen Benjamin Grünhagel Janna M Claussen Marcus Altfeld Nicolaus Kröger

Published in: Biology of sex differences (2024)

Our results demonstrate that CD99 is sex-specifically regulated in healthy individuals and MS patients and that it is involved in T cell costimulation in humans but not in mice. CD99 could potentially contribute to MS incidence and susceptibility in a sex-specific manner.

Keyphrases

multiple sclerosis
end stage renal disease
mass spectrometry
chronic kidney disease
ms ms

ejection fraction
newly diagnosed
nk cells
risk factors

prognostic factors
transcription factor
metabolic syndrome
type diabetes

white matter
adipose tissue
patient reported outcomes
high fat diet induced