Incidence, pathogens and antimicrobial resistance of blood and cerebrospinal fluid isolates from a tertiary neonatal unit in South Africa: A 10 year retrospective review.
Reenu ThomasClaude Ondongo-EzhetNini MotsoalediMike SharlandMichelle ClementsSithembiso VelaphiPublished in: PloS one (2024)
There has been a marked overall increase in rates of blood and/or CSF infections, with an absolute increase in Gram-negative infections observed, replacing Gram-positive and fungal pathogens. Extended spectrum beta-lactamase Gram-negative isolates are being replaced by carbapenem resistance, with around one third of all significant Gram-negative isolates now carbapenem resistant. Research into hospital based novel treatment and prevention interventions for neonatal sepsis should be urgently prioritized.
Keyphrases
- gram negative
- antimicrobial resistance
- multidrug resistant
- cerebrospinal fluid
- south africa
- acinetobacter baumannii
- drug resistant
- genetic diversity
- klebsiella pneumoniae
- acute kidney injury
- intensive care unit
- risk factors
- physical activity
- septic shock
- hiv positive
- escherichia coli
- combination therapy
- cystic fibrosis
- hepatitis c virus
- human immunodeficiency virus
- cell wall
- smoking cessation