Circulating regulatory T cells predict efficacy and atypical responses in lung cancer patients treated with PD-1/PD-L1 inhibitors.

Da Hyun Kang Chaeuk ChungPureum SunDa Hye LeeSong-I Lee Dong Il Park Jeong Suk Koh Yoonjoo Kim Hyon Seung Yi Jeong Eun Lee

Published in: Cancer immunology, immunotherapy : CII (2021)

Circulating Treg cells represent a promising potential dynamic biomarker to predict efficacy and differentiate atypical responses, including pseudoprogression and hyperprogression, after immunotherapy in patients with NSCLC.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
small cell lung cancer
cell cycle arrest
cell proliferation
immune response
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell death