Visit-to-Visit Blood Pressure Variability and Longitudinal Tau Accumulation in Older Adults.

Published in: Hypertension (Dallas, Tex. : 1979) (2021)

BPV is related to tau accumulation in brain regions vulnerable to Alzheimer disease, independent of average blood pressure. APOEϵ4 modified this relationship. Bidirectionality of findings is possible. BPV may represent a marker of vascular dysfunction related to early-stage tau pathology contributing to Alzheimer disease.

Keyphrases

blood pressure
early stage
cerebrospinal fluid
mild cognitive impairment
hypertensive patients
heart rate
cognitive decline
high fat diet
blood glucose
type diabetes
radiation therapy
multiple sclerosis
sentinel lymph node
metabolic syndrome
blood brain barrier
weight loss
insulin resistance
brain injury