Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells.

Bohkyung KimMinkyung BaeYoung-Ki ParkHang MaTao YuanNavindra P SeeramJi Young Lee

Published in: European journal of nutrition (2017)

mTORC1-dependent post-transcriptional induction of LDLR by BCE anthocyanins drove the transport of LDL-derived cholesterol to the apical side of the enterocytes. This may represent a potential mechanism for the hypocholesterolemic effect of BCE.

Keyphrases

low density lipoprotein
induced apoptosis
gene expression
transcription factor
cell cycle arrest
climate change