Host transcriptome signatures in human faecal-washes predict histological remission in patients with IBD.

Bella UngarMiri YavzoriElla FudimOrit PicardUri KopylovRami EliakimDror ShouvalYishai LevinAlon SavidorShani Ben-MosheRita MancoStav DanAdi EgoziKeren Bahar HalpernChen MayerIris BarshackShomron Ben-Horin Shalev Itzkovitz

Published in: Gut (2022)

Faecal wash host transcriptome is a statistically powerful biomarker reflecting histological inflammation. Furthermore, it opens the way to identifying important correlates and therapeutic targets that may be obscured using biopsy transcriptomics.

Keyphrases

single cell
genome wide
rna seq
endothelial cells
gene expression
oxidative stress
ulcerative colitis
dna methylation
induced pluripotent stem cells
disease activity
ultrasound guided
rheumatoid arthritis
fine needle aspiration
systemic lupus erythematosus