Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

Duygu KoseHarun UnRustem Anil UganZekai HaliciElif CadirciTugba Bal TastanAysenur Kahramanlar

Published in: The Journal of pharmacy and pharmacology (2022)

The GSH level and SOD activity increased while the MDA level and the expressions of TNF-α and NFK-b were reduced in the groups treated with APRE, especially in the CLP + APRE40 group. The histopathology results supported the molecular and biochemical results.

Keyphrases

anti inflammatory
rheumatoid arthritis
lipopolysaccharide induced
oxidative stress
chemotherapy induced
breast cancer cells
single molecule
fluorescent probe
inflammatory response
cell proliferation
adverse drug
cell cycle arrest
electronic health record