Effect of sodium selenite on synaptic plasticity and neurogenesis impaired by hypothyroidism.

Ercan Babur Özlem Canöz Burak Tan Cem Süer Nurcan Dursun

Published in: The International journal of neuroscience (2020)

These findings suggest that selenium supplementation in hypothyroid patients may improve learning and memory disorders with different physiological mechanisms.HighlightsSe increased serum fT3 levels and hippocampus Se levels in hypothyroid rats.Se attenuated impairment of population spike-LTP in hypothyroid ratsHypothyroidism disrupts neurogenesis process in the dentate gyrus of hippocampus.Se supplementation could not increase new born cells in hypothyroid rats.

Keyphrases

cerebral ischemia
end stage renal disease
induced apoptosis
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
cognitive impairment
cell cycle arrest
subarachnoid hemorrhage
oxidative stress
blood brain barrier
low birth weight
endoplasmic reticulum stress
cell proliferation
preterm birth