Feasible diet and circadian interventions reduce in vivo progression of FLT3-ITD-positive acute myeloid leukemia.
Megan RodriguezBaharan FekryBrianna MurphyMary FigueroaTiewei ChengMargaret RaberLisa WartenbergDonna BellLisa TricheKarla CrawfordHuaxian MaKendra AlltonRuwaida AhmedJaime TranChristine RanieriMarina KonoplevaMichelle BartonCesar NunezKristin Eckel-MahanJoya ChandraPublished in: Cancer medicine (2024)
Mouse models for FLT3-ITD AML show that diet composition and timing slows progression of FLT3-ITD AML growth in vivo, potentially mediated by BMAL1. These interventions to enhance therapy efficacy show preliminary feasibility, as pediatric leukemia patients responded favorable to preparation of macronutrient matched meals.
Keyphrases
- acute myeloid leukemia
- physical activity
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- weight loss
- newly diagnosed
- ejection fraction
- mouse model
- chronic kidney disease
- peritoneal dialysis
- stem cells
- mass spectrometry
- acute lymphoblastic leukemia
- high resolution
- patient reported
- molecularly imprinted