Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing.
Rebekah M MartinKristina BurkeDinesh VermaHeng XieJanine LangerRobert SchlabergSankar SwaminathanKimberly E HansonPublished in: Open forum infectious diseases (2020)
Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications.