Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs.

Tamara T LahValentina FaoroEvgenia BourkoulaNeža PodergajsTamara IusMarco VindigniMiran SkrapTamara LahDaniela CesselliPaola StoriciAlessandro Vindigni
Published in: Cancer cell international (2016)
We suggest that Top2β may represent a new target for gene therapy in glioblastoma. In addition, the other genes that we found to be up-regulated in GSC versus glioblastoma primary cells should be further investigated as glioblastoma theranostics.