Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer.

Zhihao LuHuan ChenShuang LiJifang GongJian LiJianling ZouLihong WuJianing YuWenbo HanHuaibo SunXi JiaoXiaotian ZhangZhi PengMing LuZhenghang WangHenghui ZhangLin Shen

Published in: Journal for immunotherapy of cancer (2021)

Our results suggest that the burden of CNA may have superior predictive value compared with other signatures, including PD-L1, MSI and TMB. The joint biomarker of CNA burden and TMB may better stratify DCB patients, thereby providing a rational choice for GI patients treated with ICBs.

Keyphrases

copy number
mitochondrial dna
end stage renal disease
genome wide
ejection fraction
newly diagnosed
chronic kidney disease
papillary thyroid
prognostic factors
risk factors
peritoneal dialysis
squamous cell carcinoma
gene expression
squamous cell
patient reported