Redefinition of familial intestinal gastric cancer: clinical and genetic perspectives.

Joana CarvalhoPatricia OliveiraJanine SenzCelina São JoséSamantha HansfordSara Pinto TelesMarta FerreiraGiovanni Corso Hugo PinheiroDiana LemosValeria PascaleFranco RovielloDavid HuntsmanCarla Oliveira

Published in: Journal of medical genetics (2020)

This study proposed the first data-driven testing criteria for FIGC families, and supported FIGC as a genetically determined, likely polygenic, gastric cancer-predisposing disease, with earlier onset and distinct from patients with SIGC at the germline and somatic levels.

Keyphrases

copy number
genome wide
dna methylation
gene expression
oxidative stress