Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways.

Xiao-Lei SunJia-Bao ZhangYun-Xiang GuoTian-Shuang XiaLing-Chuan XuKhalid RahmandGuo-Ping WangXiao-Jin LiTing HanNa-Ni WangHai-Liang Xin

Published in: The Journal of pharmacy and pharmacology (2022)

Xanthohumol effectively ameliorates memory impairment of APP/PS1 mice by activating mTOR/LC3 and Bax/Bcl-2 signalling pathways, which provides new insight into the neuroprotective effects of Xanthohumol.

Keyphrases

high fat diet induced
working memory
cell proliferation
simultaneous determination
mouse model
induced apoptosis
signaling pathway
mass spectrometry
liquid chromatography
metabolic syndrome
insulin resistance
wild type
adipose tissue
cerebral ischemia
high resolution
blood brain barrier