Sensory Ion Channel Candidates Inform on the Clinical Course of Pancreatic Cancer and Present Potential Targets for Repurposing of FDA-Approved Agents.

Wenjie ShiChen LiThomas WartmannChristoph KahlertRenfei DuAristotelis PerrakisThomas BrunnerRoland Siegfried Croner Ulf Dietrich Kahlert

Published in: Journal of personalized medicine (2022)

Our computational pipeline constructed a four TRP-related gene signature that enables us to predict clinical prognostic value of hitherto unrecognized biomarkers for PAAD. Sensory ion channels TRPC3 and TRPC7 could be the potential therapeutic targets in pancreatic cancer and TRPC3 might be involved in dysregulating mitochondrial functions during PAAD genesis.

Keyphrases

vascular smooth muscle cells
oxidative stress
human health
wastewater treatment
genome wide
dna methylation
risk assessment
angiotensin ii
transcription factor