Association Between Smoking and Molecular Subtypes of Colorectal Cancer.
Xiaoliang WangEfrat L AmitayTabitha A HarrisonBarbara L BanburySonja I BerndtHermann BrennerDaniel D BuchananPeter T CampbellYin CaoAndrew T ChanJenny Chang-ClaudeSteven J GallingerMarios GiannakisGraham G GilesMarc J GunterJohn L HopperMark E JenkinsYi LinVictor MorenoReiko NishiharaPolly A NewcombShuji OginoAmanda I PhippsLori C SakodaRobert E SchoenMartha L SlatteryMingyang SongWei SunSteven N ThibodeauAmanda Ewart TolandBethany Van GuelpenMichael O WoodsLi HsuMichael HoffmeisterUlrike PetersPublished in: JNCI cancer spectrum (2021)
Smoking was associated with differential risk of CRC subtypes defined by molecular characteristics. Heavier smokers had particularly higher risk of CRC subtypes that were CIMP positive and MSI high in combination, suggesting that smoking may be involved in the development of colorectal tumors via the serrated pathway.
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