Epigenetic heterogeneity hotspots in human liver disease progression.

Ryan A HladyXia ZhaoLouis Y El Khoury Ryan T WagnerAesis LunaKien PhamNikolaos T PyrosopoulosDhanpat Jain Liguo Wang Chen Liu Keith D Robertson

Published in: Hepatology (Baltimore, Md.) (2024)

Substantial epigenetic heterogeneity arises early in liver disease development, targeting key pathways in the progression and initiation of both cirrhosis and HCC. Integration of epigenetic and transcriptional heterogeneity unveils putative epigenetic regulators of hepatocarcinogenesis.

Keyphrases

dna methylation
gene expression
single cell
transcription factor
cancer therapy
heat stress