Single Fraction and Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, and Reduced Viability of Merlin-Deficient Schwann Cells.

Christine T DinhSi ChenAida NourbakhshKyle PadgettPerry JohnsonStefania GoncalvesOlena BrachoEsperanza BasJorge BohorquezPaula V MonjeCristina Fernandez-ValleNagy ElsayyadXue Zhong LiuScott M WelfordFred Telischi

Published in: Cancers (2023)

Investigations into the mechanisms of radiation ototoxicity and VS radiobiology will help determine optimal radiation regimens and identify potential therapies to mitigate radiation-induced HL and improve VS tumor control.

Keyphrases

radiation induced
radiation therapy
hearing loss
induced apoptosis
oxidative stress
risk assessment
small cell lung cancer
peripheral nerve
human health