MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.

Claire Amaris HobsonL VigueS NaimiB ChassaingM MagnanS BonacorsiB GachetI El MeoucheA BirgyO Tenaillon

Published in: JAC-antimicrobial resistance (2022)

MBRA can reliably mimic the intestinal microbiota and its modifications under antibiotic selective pressure. The impact of the treatment was donor- and concentration-dependent. We hypothesize these results could be explained, at least in part, by the differences in β-lactamase activity of the microbiota itself. Our results support the relevance and promise of the MBRA system to study drug-microbiota interactions.

Keyphrases

escherichia coli
emergency department
machine learning
multidrug resistant
mass spectrometry
artificial intelligence
replacement therapy
electronic health record