Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.

Dean C SingletonAnne-Lise DechaumePamela M MurrayWilliam P KattBruce C BaguleyEuphemia Y Leung

Published in: BMC cancer (2020)

This study highlights the potential influence that both circulating and tumour-derived pyruvate can have on glutaminase inhibitor efficacy. Furthermore, it highlights the benefits of 3D spheroid cultures to model the features of the tumour microenvironment and improve the in vitro investigation of cancer metabolism-targeted therapeutics.

Keyphrases

papillary thyroid
stem cells
small molecule
squamous cell
risk assessment
human health
lymph node metastasis
binding protein
young adults