Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.

Blerina Shkodra-PulaChristian KretzerPaul M JordanPaul KlemmAndreas KoeberleDavid PretzelErden BanogluStefan LorkowskiMaria WallertStephanie HöppenerSteffi StumpfAntje VollrathStephanie SchubertOliver WerzUlrich Sigmar Schubert

Published in: Journal of nanobiotechnology (2020)

Our results demonstrate that encapsulation of BRP-187 into Acdex and PLGA is feasible, and both PLGA- and Acdex-based particles loaded with BRP-187 are more efficient in suppressing 5-lipoxygenase product formation and prostaglandin E2 biosynthesis in intact cells as compared to the free compound, particularly after prolonged preincubation periods.

Keyphrases

drug delivery
drug release
induced apoptosis
cancer therapy
bone regeneration
cell cycle arrest
signaling pathway
oxidative stress
wound healing