Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats.

Isabell Vargas ChristensenMette LoftagerFrederik RodeHanne Mørck NielsenMads KreilgaardMalte Selch Larsen

Published in: Journal of thrombosis and haemostasis : JTH (2019)

We developed a population-based PK model describing the time-course of total rFVIII, total VWF, and the rFVIII:VWF complex over a broad range of rFVIII doses in hemophilia A rats.

Keyphrases

cell free
binding protein