Salvianolic acid B as a potent nano-agent for enhanced ALA-PDT of oral cancer and leukoplakia cells.

Ying Zhang Sai YeYongmei ZhouZengtong ZhouYilin YaoWei Liu Lan Wu

Published in: Oral diseases (2023)

The novel photosensitizer nano-SalB-ALA remarkably enhanced the efficacy of PDT by improving singlet oxygen production, inhibiting cell proliferation, promoting cell apoptosis, and suppressing tumor growth. These suggest PDT with nano-SalB-ALA could be a clinically significant and potent treatment for oral cancer and leukoplakia.

Keyphrases

photodynamic therapy
cell proliferation
induced apoptosis
signaling pathway
cell cycle arrest
anti inflammatory
cell cycle
oxidative stress
combination therapy
replacement therapy