Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy.
Binbin LinYuting WangPiao ZhangYanyan YuanYing ZhangGang ChenPublished in: The journal of headache and pain (2020)
Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unfortunately, the precise pathogenesis of NP has not been elucidated. Currently, the microbiota-gut-brain axis has drawn increasing attention, and the emerging role of gut microbiota is investigated in numerous diseases including NP. Gut microbiota is considered as a pivotal regulator in immune, neural, endocrine, and metabolic signaling pathways, which participates in forming a complex network to affect the development of NP directly or indirectly. In this review, we conclude the current understanding of preclinical and clinical findings regarding the role of gut microbiota in NP and provide a novel therapeutic method for pain relief by medication and dietary interventions.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- physical activity
- signaling pathway
- healthcare
- mental health
- oxidative stress
- risk assessment
- chronic pain
- epithelial mesenchymal transition
- working memory
- emergency department
- pain management
- depressive symptoms
- cell proliferation
- bone marrow
- pi k akt
- brain injury
- mesenchymal stem cells
- resting state
- subarachnoid hemorrhage
- drug induced