Rivaroxaban versus aspirin for prevention of covert brain infarcts in patients with embolic stroke of undetermined source: NAVIGATE ESUS MRI substudy.
Mukul SharmaEric E SmithLesly A PearceKanjana S PereraScott E KasnerByung-Woo YoonSebastián Francisco AmerisoJosep PuigDorte DamgaardJochen B FiebachKeith W MuirRoland C VeltkampDanilo S ToniNikolay ShamalovRubens J GagliardiRobert MikulikStefan T EngelterDániel BereczkiMartin J O'DonnellFeryal SaadAshkan ShoamaneshScott D BerkowitzHardi MundlRobert G Hartnull nullPublished in: International journal of stroke : official journal of the International Stroke Society (2021)
Incident covert brain infarcts occurred in twice as many ESUS patients as a clinical ischemic stroke. Treatment with rivaroxaban compared with aspirin did not significantly reduce the incidence of covert brain infarcts or increase the incidence of microbleeds, but the confidence intervals for treatment effects were wide.Registration: https://www.clinicaltrials.gov. Unique identifier: NCT02313909.
Keyphrases
- atrial fibrillation
- white matter
- low dose
- end stage renal disease
- resting state
- venous thromboembolism
- cerebral ischemia
- risk factors
- ejection fraction
- pulmonary embolism
- magnetic resonance imaging
- chronic kidney disease
- cardiovascular events
- newly diagnosed
- peritoneal dialysis
- antiplatelet therapy
- prognostic factors
- multiple sclerosis
- computed tomography
- anti inflammatory drugs