NO-mediated signal transmission in bladder vasculature as a therapeutic target of PDE5 inhibitors. Rodent model studies.

Hidekazu TanakaRetsu MitsuiMitsuhiro OishiStefan PasslickRonald Jabs Christian Steinhäuser Kenji F Tanaka Hikaru Hashitani

Published in: British journal of pharmacology (2021)

Both nitrergic nerve and nerve-evoked endothelial NO release appear to be involved in vasodilatory signal transmission in bladder vasculature. The NO-mediated signal transmission is a potential target for PDE5 inhibitor therapy in bladder dysfunctions.

Keyphrases

spinal cord injury
urinary tract
peripheral nerve
endothelial cells
climate change