Targeted delivery of edaravone by liposomes for the treatment of ischemic stroke.
Meng-Meng SongJing ChenShu-Ming YeDa-Peng LuGui-Yang ZhangRui LiuYu-Xian ShenPublished in: Nanomedicine (London, England) (2022)
Aim: To construct an edaravone-encapsulated liposomes (EDV-LIPs) formulation against acute ischemic stroke. Methods: EDV-LIPs were prepared by the film dispersion method. The biosafety was evaluated both in vitro and in vivo by flow cytometry and the histological staining method. Biodistribution and therapeutic effect of EDV-LIPs against acute ischemic stroke was investigated by fluorescent imaging, the behavior test, laser speckle imaging and triphenyltetrazolium chloride staining. Results: The nanoliposomes had a long circulation time and could accumulate in the brain lesion region in ischemic stroke rats. EDV-LIPs show good biosafety. EDV-LIPs could restore more cerebral blood flow, reduce infarct volume and decrease neuronal apoptosis. Conclusion: EDV-LIPs provide an effective alternative for drug-targeted delivery against acute ischemic stroke.
Keyphrases
- acute ischemic stroke
- flow cytometry
- drug delivery
- cerebral blood flow
- high resolution
- atrial fibrillation
- oxidative stress
- acute myocardial infarction
- emergency department
- multiple sclerosis
- white matter
- cell proliferation
- computed tomography
- cerebral ischemia
- mass spectrometry
- left ventricular
- coronary artery disease
- signaling pathway
- electronic health record