Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease.
Amy H AttawayAnnette BellarNicole WelchJinendiran SekarAvinash KumarSaurabh MishraUmur HatipoğluMerry-Lynn McDonaldElizabeth A ReganJonathan D SmithGeorge WashkoRaúl San José EstéparPeter BazeleyJoe ZeinSrinivasan DasarathyPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Genetic polymorphisms of FTO and AC090771.2 were associated with sarcopenia in COPD in independent cohorts. Knockdown of FTO in murine myotubes caused a molecular phenotype consistent with senescence that was exacerbated by hypoxia, a common condition in COPD. Genetic variation may interact with hypoxia and contribute to variable severity of sarcopenia and skeletal muscle molecular senescence phenotype in COPD.