Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease.
Patrick L HeilmanErnest W WangMechelle M LewisStanislaw KrzyzanowskiColt D CapanAmanda R BurmeisterGuangwei DuMartha L Escobar GalvisPatrik BrundinXuemei HuangLena BrundinPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
In PD, the kynurenine pathway metabolite levels are altered in both the periphery and the central nervous system, and these changes are associated with symptom severity. Replication studies are warranted in other cohorts, and these can also explore if kynurenine metabolites might be PD biomarkers and/or are involved in PD pathogenesis. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.