Clinical, pathological and gene expression profiling of estrogen receptor discordance in breast cancer.

Xi WangShengnan BaoMengping JiangXian ZouYongmei Yin

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)

People in two cohorts from JSPH presented different clinical characteristics and prognosis. The gene KMT2C may affect the progression of BC by regulating the molecular, epigenetic activity and immune infiltration. It may also serve as a novel prognostic biomarker for BC patients who underwent ER status converted from positive to negative.

Keyphrases

estrogen receptor
gene expression
dna methylation
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
genome wide
prognostic factors
copy number
patient reported outcomes
young adults
single molecule
genome wide analysis
childhood cancer