CNP Ameliorates Macrophage Inflammatory Response and Atherosclerosis.

Qiankun Bao Bangying ZhangLu ZhouQian YangXiaofeng MuXing LiuShiying ZhangMeng YuanYue ZhangJingjin CheWen WeiTong LiuGuangping LiJinlong He

Published in: Circulation research (2024)

Our study reveals that CNP enhanced plaque stability and alleviated macrophage inflammatory responses by promoting HIF-1α degradation, suggesting a novel atheroprotective role of CNP. Enhancing CNP bioactivity may offer a novel pharmacological strategy for treating related diseases.

Keyphrases

inflammatory response
adipose tissue
lipopolysaccharide induced
mouse model
type diabetes
toll like receptor
immune response
drug induced