Growth hormone-Insulin-like growth factor 1 axis hyperactivity on bone fibrous dysplasia in McCune-Albright Syndrome.

Daniele TessarisAlison M BoyceMargaret ZacharinPatrizia MatarazzoRoberto LalaLuisa De SanctisMichael T Collins

Published in: Clinical endocrinology (2018)

GH-IGF1 hyperactivity increases risk of morbidities in MAS. Medical therapy is effective in normalizing IGF1 in most patients, and early treatment during paediatric age is associated with a decreased risk of optic neuropathy and GH-secreting adenomas growth.

Keyphrases

growth hormone
end stage renal disease
ejection fraction
emergency department
newly diagnosed
healthcare
peritoneal dialysis
stem cells
cell proliferation
patient reported outcomes
binding protein
cell therapy
combination therapy
patient reported