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'Off-the-shelf' allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies.

Debottam SinhaSriganesh SrihariKirrliee BeckettLaetitia Le TexierMatthew SolomonArchana PanikkarGeorge R AmbalathingalLea LekieffrePauline CrooksSweera RehanMichelle A NellerCorey SmithRajiv Khanna
Published in: Journal for immunotherapy of cancer (2021)
These findings suggest that restriction switching by sequential infusion of allogeneic T-cell therapies that target EBV through distinct HLA alleles may improve clinical response.
Keyphrases
  • stem cell transplantation
  • epstein barr virus
  • bone marrow
  • diffuse large b cell lymphoma
  • hematopoietic stem cell
  • high dose
  • low dose
  • cell therapy
  • replacement therapy