Two neolignan glycosides including a new one ( 1 ), along with seven iridoid glycosides ( 3 - 9 ) and nine flavonoid glycosides ( 10 - 18 ), were isolated from the leaves of Vaccinium bracteatum . Their structures were established mainly on the basis of 1D/2D NMR and ESIMS analyses, as well as comparison to known compounds in the literature. The structure of 1 with absolute stereochemistry was also confirmed by chemical degradation and ECD calculation. Selective compounds showed antiradical activity against ABTS and/or DPPH. Moreover, several isolates also suppressed the production of ROS in RAW264.7 cells and exerted neuroprotective effect toward PC12 cells.