Detection of Autophagy-Related Gene Expression by Conjunctival Impression Cytology in Age-Related Macular Degeneration.
Chih-Wen ShuYoun-Shen BeeJiunn-Liang ChenChui-Lien TsenWei-Lun TsaiShwu-Jiuan SheuPublished in: Diagnostics (Basel, Switzerland) (2021)
Our study showed the possibility of assessing autophagy-related gene expression by conjunctival impression cytology. GABARAPL1 was significantly higher in AMD. Although an in vitro study showed an initial protective effect of autophagy, a cell viability study revealed the possibility of a harmful effect after long-term oxidative injury. The underlying mechanism or critical factors require further investigation.