Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma.
Handan XiangYidan PanMarc A SzeMarta WlodarskaLing LiKaryn Ann van de MarkHaleema QamarCasey J MoureDouglas E LinnJosephine HaiYing HuoJames ClarkeTze Guan TanSamantha HoKaren W TengMuhammad Nadzim RamliMichael NebozhynChunsheng ZhangJulianne BarlowCorinne E GustafsonSavanna GornisiewiczThomas P AlbertsonStephanie L KorleRaphael BuenoLily Y MoyElisabeth H VollmannDerek Y ChiangPhilip E BrandishAndrey LobodaPublished in: Cancer research (2024)
NOTCH3 signaling activates tumor-associated mesenchymal cells, increases collagen production, and augments cell invasion in lung adenocarcinoma, suggesting its critical role in remodeling tumor stroma.