Evidence for a role of eosinophils in blister formation in bullous pemphigoid.
E de GraauwC SitaruM HornL BorradoriShida YousefiH-U SimonDagmar SimonPublished in: Allergy (2017)
Our results provide evidence that IL-5-activated eosinophils directly contribute to BP blister formation in the presence of BP autoantibodies. Dermal-epidermal separation by IL-5-activated eosinophils depends on adhesion and Fcγ receptor activation, requires elevated ROS production and degranulation and involves EET formation. Thus, targeting eosinophils may be a promising therapeutic approach for BP.