Environmental Factors Associated With Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project.
Mingyue XueHaim LeibovitzhShao JingchengAnna NeustaeterMei DongWei XuOsvaldo Espin-GarciaAnne M GriffithsA Hillary SteinhartDan TurnerHien Q HuynhLevinus A DielemanRemo PanaccioneGuy AumaisBrian BresslerAlain BittonSanjay MurthyJohn K MarshallJeffrey S HyamsAnthony OtleyCharles N BernsteinPaul MoayyediWael El-MataryAlexander FichLee A DensonMark J RopeleskiMaria T AbreuColette DeslandresMaria CinoIrit Avni-BironSun-Ho LeeWilliams Turpinnull nullKenneth CroitoruPublished in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2024)
This study identifies environmental variables associated with CD risk. These variables were also associated with altered barrier function, subclinical inflammation, and gut microbiome composition shifts, suggesting potential roles in CD pathogenesis.