High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.

Simon Paul KeamHeloise HalseThu NguyenMinyu WangNicolas Van Kooten LosioCatherine MitchellFranco CaramiaDavid J ByrneSue HauptGeorgina RylandPhillip K DarcyShahneen SandhuPiers BlomberyYgal HauptScott G WilliamsPaul Joseph Neeson

Published in: Journal for immunotherapy of cancer (2021)

In conclusion, we showed HDRBT converted "cold" prostate tumors into more immunologically activated "hot" tissues, with accompanying spatially organized immune infiltrates and signaling changes. Understanding and potentially harnessing these changes will have widespread implications for the future treatment of localized PCa, including rational use of combination radio-immunotherapy.

Keyphrases

high dose
prostate cancer
radical prostatectomy
stem cell transplantation
low dose
gene expression
radiation therapy
big data
benign prostatic hyperplasia
locally advanced
artificial intelligence