Inflammation and blood-brain-barrier in depression - interaction of CLDN5 and IL6 gene variants in stress-induced depression.

These findings provide genetic evidence in humans for the interaction among interleukin-6, claudin-5 and recent stress, suggesting that inflammation is involved in the development of depression, and stress-connected brain entry of inflammatory molecules is a key factor in this pathomechanism. These genetic polymorphisms may help to identify people at higher risk for recent stress-induced depression.