Extracellular microvesicle microRNAs as predictive biomarkers for targeted therapy in metastastic cutaneous malignant melanoma.

Fernanda Costa Svedman Warangkana LohcharoenkalMatteo BottaiSuzanne Egyhazi BrageEnikö SonkolyJohan HanssonAndor PivarcsiHanna Eriksson

Published in: PloS one (2018)

EV miRNAs let-7g-5p and miR-497-5p were identified as putative novel predictive biomarkers of MAPKi treatment benefit in metastatic CMM patients highlighting the potential relevance of assessing EV miRNA during and after treatment to unravel novel mechanisms of resistance.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
squamous cell carcinoma
small cell lung cancer
chronic kidney disease
peritoneal dialysis
risk assessment
patient reported outcomes
combination therapy
human health