Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine.

Francis MwimanziHope R LapointePeter K CheungYurou SangFatima YaseenRebecca KalikaweSneha DatwaniLaura BurnsLandon YoungVictor LeungSiobhan EnnisChanson J BrummeJulio S G MontanerWinnie DongNatalie PrystajeckyChristopher F LoweMari L DeMarcoDaniel T HolmesJanet SimonsMasahiro NiikuraMarc G RomneyZabrina L BrummeMark A Brockman

Published in: Open forum infectious diseases (2023)

Results underscore the immune benefits of the third COVID-19 mRNA vaccine dose in adults of all ages and identify vaccine-induced Omicron-specific neutralization as a correlate of protective immunity. Systemic antibody responses and functions however, particularly Omicron-specific neutralization, decline rapidly in COVID-19-naive individuals, particularly in older adults, supporting the need for additional booster doses.

Keyphrases

coronavirus disease
respiratory syndrome coronavirus
immune response
sars cov
physical activity
toll like receptor
binding protein
drug induced
dendritic cells
endothelial cells