Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo.
Elene KakabadzeKhatuna MakalatiaNino GrdzelishviliNata BakuradzeMarina GoderdzishviliIa KusradzeMarie-France PhobaOctavie LunguyaCédric LoodRob LavigneJan JacobsStijn DeborggraeveTessa De BlockSandra Van PuyveldeDavid LeeAidan CoffeyAnahit SedrakyanPatrick SoentjensDaniel De VosJean-Paul PirnayNina ChanishviliPublished in: Viruses (2018)
Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.